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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3R3 All Species: 26.97
Human Site: Y391 Identified Species: 74.17
UniProt: Q92569 Number Species: 8
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92569 NP_001107644.1 461 54462 Y391 E S S K K G C Y A C S V V A D
Chimpanzee Pan troglodytes XP_517729 724 83607 R642 E N L L R G K R D G T F L V R
Rhesus Macaque Macaca mulatta XP_001107121 461 54420 Y391 E S S K K G C Y A C S V V A D
Dog Lupus familis XP_539629 461 54435 Y391 E S S K K G C Y A C S V V A D
Cat Felis silvestris
Mouse Mus musculus Q64143 461 54456 Y391 E S S K K G C Y A C S V V A D
Rat Rattus norvegicus Q63789 461 54236 Y391 E S S K K G C Y A C S V V A D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_426652 737 84066 Y666 E S S K K G C Y A C S V V A D
Frog Xenopus laevis Q8UUU2 722 83110 R640 E N L L R G K R D G T F L V R
Zebra Danio Brachydanio rerio NP_957437 464 54712 Y393 E S S K K G C Y A C S V V V E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 49.3 99.5 98.9 N.A. 96 95 N.A. N.A. 55.7 48.3 86.6 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 56.9 99.5 99.3 N.A. 98.4 97.6 N.A. N.A. 60.6 56 93.9 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 13.3 100 100 N.A. 100 100 N.A. N.A. 100 13.3 86.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 40 100 100 N.A. 100 100 N.A. N.A. 100 40 93.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 78 0 0 0 0 67 0 % A
% Cys: 0 0 0 0 0 0 78 0 0 78 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 23 0 0 0 0 0 67 % D
% Glu: 100 0 0 0 0 0 0 0 0 0 0 0 0 0 12 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 23 0 0 0 % F
% Gly: 0 0 0 0 0 100 0 0 0 23 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 78 78 0 23 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 23 23 0 0 0 0 0 0 0 0 23 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 23 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 23 0 0 23 0 0 0 0 0 0 23 % R
% Ser: 0 78 78 0 0 0 0 0 0 0 78 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 23 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 78 78 34 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 78 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _